Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis
نویسندگان
چکیده
Caryn Bern, Jill Adler-Moore, Juan Berenguer, Marleen Boelaert, Margriet den Boer, Robert N. Davidson, Concepcion Figueras, Luigi Gradoni, Dimitris A. Kafetzis, Koert Ritmeijer, Eric Rosenthal, Catherine Royce, Rosario Russo, Shyam Sundar, and Jorge Alvar Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; California State Polytechnic University, Pomona; Hospital Gregorio Marañón, Madrid, and Hospital Vall D’Hebrón, Barcelona, Spain; Institute for Tropical Medicine, Antwerp, Belgium; Médecins sans Frontières–Holland, Amsterdam, The Netherlands; Department of Infection and Tropical Medicine, Northwick Park Hospital, Harrow, Middlesex, United Kingdom; Istituto Superiore di Sanità, Rome, and Istituto Malattie Infettive, Catania, Italy; Kyriakou Children’s Hospital, Athens, Greece; Archet Hospital and Equipes de Recherche sur les Leishmanioses, University of Nice, Nice, France; Drugs for Neglected Diseases Initiative and Communicable Diseases, Neglected Tropical Diseases Control, World Health Organization, Geneva, Switzerland; and Banaras Hindu University, Vanarasi, India
منابع مشابه
Recurrent visceral leishmaniasis in an immunocompetent patient: a case report
INTRODUCTION Current treatment options for visceral leishmaniasis (pentavalent antimony, amphotericin B, liposomal amphotericin B and mitelfosine) achieve long-term clinical cure in the majority of immunocompetent patients. Disease relapse is usually provoked by T-cell number or function impairment (corticosteroid or cytotoxic therapy, transplant recipients, advanced human immunodeficiency viru...
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KEY CLINICAL MESSAGE Successful management of cases with visceral leishmaniasis (VL) and tuberculosis is a challenge for clinicians, because a guideline for that is currently unavailable. We report the first case in Bangladesh who developed VL during her treatment for pulmonary tuberculosis and was treated successfully with multidose liposomal amhptericin B for VL.
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Visceral Leishmaniasis (VL) is an opportunistic infection amongst HIV-infected people in several endemic countries, and the clinical management of this co-infection poses several challenges. Here we describe a co-infected patient in India who failed to respond to miltefosine monotherapy and subsequently relapsed following two further (different) regimens of liposomal amphotericin B. He was then...
متن کاملAntimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B
We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse events and resulted in rapid and sustained clinical and parasitological cure.
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Leishmaniasis is a neglected public health problem caused by the protozoan species belonging to the genus Leishmania affecting mostly the poor populations of developing countries. The causative organism is transmitted by female sandflies. Cutaneous, mucocutaneous, and visceral clinical manifestations are the most frequent forms of leishmaniasis. Chemotherapy still relies on the use of pentavale...
متن کاملFoamy histiocytes in a patient with visceral leishmaniasis after treatment with liposomal amphotericin B.
A seven-year-old patient was admitted to our hospital with the complaints of fever, malaise, and abdominal distention. In the bone marrow aspiration smears, leishmania amastigotes were observed. The patient was diagnosed as having visceral leishmaniasis (VL) and treated with liposomal amphotericin B (L-AMB). The authors report their observation of foamy histiocytes seen in the bone marrow aspir...
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